Mr Brown and Mr Darling in March 2010 ahead of the General Election.
According to extracts seen by Labour Uncut, Mr Darling will claim Mr Brown's moods became increasingly "brutal and volcanic" in 2008.
'Back from the Brink: 1,000 Days at No 11' is said to detail a complete breakdown in trust between the Prime Minister and Chancellor.
Mr Darling reportedly singles out Ed Balls and Shriti Vadhera as key allies of Mr Brown, who he says were running what amounted to a parallel Treasury within Government.
He claims to have refused to have Ms Vadhera in his team, describing her as "only happy if there was blood on the floor - preferably that of her colleagues".
Alistair Darling's memoirs should give Ed Miliband some concerns about Ed Balls' suitability to be shadow chancellor.Conservative party chairman Baroness Warsi
Yvette Cooper was accepted as chief secretary to the treasury in January 2008, but Mr Darling reportedly says she was put there to "keep an eye" on him.
He also allegedly confirms the widely reported rumour that in 2009 Mr Brown tried to sack him as chancellor and offer him another junior role in cabinet.
Mr Darling threatened to walk out of government and Mr Brown, severely weakened by the economic crisis and plummeting poll ratings, relented and let him remain at No 11.
Karen Duffy, the publicity director of publisher Atlantic books, said she was unable to comment on the accuracy of the reports.
Mr Brown & Mr Balls are allegedly accused of running a parallel Treasury.
"We're not confirming or denying," she told Sky News, because the contents of the book must remain confidential because they have agreed a deal with a newspaper ahead of publication next week.
Conservative party chairman Sayeeda Warsi seized on the claims as proof that key Labour figures put party infighting above the nation's interests.
"Alistair Darling's memoirs should give Ed Miliband some concerns about Ed Balls' suitability to be shadow chancellor," she said.
"Ed Balls recently claimed that he 'did his politics on the record', but he has already been shown to have been at the heart of the plot to oust Tony Blair.
"Now Alistair Darling accuses him of running a shadow treasury operation within his own government.
"No wonder Labour left the nation's finances in such a mess when they put party political plotting above the national interest."